Long-term statins administration exacerbates diabetic nephropathy via ectopic fat deposition in diabetic mice
oleh: Tong-sheng Huang, Teng Wu, Yan-di Wu, Xing-hui Li, Jing Tan, Cong-hui Shen, Shi-jie Xiong, Zi-qi Feng, Sai-fei Gao, Hui Li, Wei-bin Cai
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
Huang et al. investigated the effects of long-term statins administration in a mouse model for diabetes and found that it can worsen insulin resistance, renal inflammation and fibrosis. Statins increased renal lipid uptake and inhibited fatty acid oxidation, contributing to diabetic nephropathy.