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Beyond CAR T Cells: Other Cell-Based Immunotherapeutic Strategies Against Cancer
oleh: Shabnum Patel, Rachel A. Burga, Allison B. Powell, Elizabeth A. Chorvinsky, Nia Hoq, Sarah E. McCormack, Stacey N. Van Pelt, Patrick J. Hanley, Conrad Russell Y. Cruz, Conrad Russell Y. Cruz
Format: | Article |
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Diterbitkan: | Frontiers Media S.A. 2019-04-01 |
Deskripsi
Background: Chimeric antigen receptor (CAR)-modified T cells have successfully harnessed T cell immunity against malignancies, but they are by no means the only cell therapies in development for cancer.Main Text Summary: Systemic immunity is thought to play a key role in combatting neoplastic disease; in this vein, genetic modifications meant to explore other components of T cell immunity are being evaluated. In addition, other immune cells—from both the innate and adaptive compartments—are in various stages of clinical application. In this review, we focus on these non-CAR T cell immunotherapeutic approaches for malignancy. The first section describes engineering T cells to express non-CAR constructs, and the second section describes other gene-modified cells used to target malignancy.Conclusions: CAR T cell therapies have demonstrated the clinical benefits of harnessing our body's own defenses to combat tumor cells. Similar research is being conducted on lesser known modifications and gene-modified immune cells, which we highlight in this review.