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Introduction and AimsEvidence based medicine aids the delivery of effective service to patients, diagnosing and treating. According to Clinical guidelines of evidence-based medicine, it’s possible to change clinical decision, improve treatment and promote the patients´ health. The purpose of this study is to survey knowledge, attitudes and performance about evidence-based medicine among physicians.Materials and MethodsAll of the physicians in educational hospitals of medical faculty of Neyshabur, were entered in this cross-descriptive study by convenience sampling method. The questionnaire included demographic information and also information about knowledge, attitudes and obstacles of evidence-based medicine. Data were analyzed by SPSS v.16 software and descriptive statistics.ResultsResults showed that 88 % of physicians had little familiarity with evidence-based medicine and its resources. 47.8 % of them employed evidence-based medicine in their treatment decisions and 60.4 % knew the significance of evidence-based medicine for medical teams. Overloud of information were reported by 55.1 % of participants as preventive factor in use of evidence-based medicine.ConclusionAccording to low level of knowledge and performance in evidence-based medicine among physicians, promoting awareness and practice is needed.* Corresponding Author: North Khorasan University of Medical Sciences, Department of Nursing and Midwifery.Email: Akramgazrany@gmail.com