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Objective: To determine the relationship between perceived stress and burden among caregivers of stroke survivors residing in Lahore city of Pakistan. Methods: This prospective cross-sectional study was conducted at three health care institutes of Lahore, Pakistan from October 2021 to March 2022. The inclusion was limited to caregivers providing more than 6 hours of care per day to stroke survivors for at least one month duration after the discharge from hospital. The Zarit Caregiver burden interview and perceived stress scale were used to measure caregiver burden and perceived stress respectively. Results: Of 384 caregivers of stroke survivors, the mean age was 34.79 ± 5.80 years. Mild to moderate burden was observed in 364 (94.8%) and only 20 (5.2%) had moderate to severe burden. Similarly, moderate stress was observed in 353 (91.9%) and only 31 (8.1%) had severe stress. A significantly weak positive correlation was found between stress score and burden score (r=0.26, p-value <0.001). Furthermore, significantly weak positive correlation of burden and stress score was observed when stratified on the basis of age, gender, and relationship with the stroke survivor. Conclusion: In the current study, a weak positive correlation was observed between perceived stress and burden among caregivers of stroke survivors.