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With the increasing application of nanoparticles (NPs) in medical and consumer applications, it is necessary to ensure their safety. As m⁶A (N⁶-methyladenosine) RNA modification is one of the most prevalent RNA modifications involved in many diseases and essential biological processes, the relationship between nanoparticles and m⁶A RNA modification for the modulation of these events has attracted substantial research interest. However, there is limited knowledge regarding the relationship between nanoparticles and m⁶A RNA modification, but evidence is beginning to emerge. Therefore, a summary of these aspects from current research on nanoparticle-induced m⁶A RNA modification is timely and significant. In this review, we highlight the roles of m⁶A RNA modification in the bioimpacts of nanoparticles and thus elaborate on the mechanisms of nanoparticle-induced m⁶A RNA modification. We also summarize the dynamic regulation and biofunctions of m⁶A RNA modification. Moreover, we emphasize recent advances in the application perspective of nanoparticle-induced m⁶A RNA modification in medication and toxicity of nanoparticles to provide a potential method to facilitate the design of nanoparticles by deliberately tuning m⁶A RNA modification.