Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor
oleh: Jia Duan, Peiyu Xu, Huibing Zhang, Xiaodong Luan, Jiaqi Yang, Xinheng He, Chunyou Mao, Dan-Dan Shen, Yujie Ji, Xi Cheng, Hualiang Jiang, Yi Jiang, Shuyang Zhang, Yan Zhang, H. Eric Xu
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
Follicle stimulating hormone (FSH) is a glycoprotein hormone the functions of which are mediated by a G protein-coupled receptor, FSHR. Here, Duan et al. report cryo-EM structures of FSHR in active and inactive states, suggesting the molecular basis of FSH and small allosteric agonist-mediated FSHR activation.