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This study evaluated the effect of <i>Artemisia absinthium</i> and <i>Malva sylvestris</i> on antioxidant response and histopathological changes in the abomasa of the <i>Haemonchus contortus</i> infected lambs. Twenty-four lambs were divided into four groups: unsupplemented lambs (UNS), lambs supplemented with <i>A. absinthium</i> (ART), lambs supplemented with <i>M. sylvestris</i> (MAL), and lambs supplemented with both plants (ARTMAL). Lambs were infected orally with approximately 5000 third-stage (L3) larvae of <i>H. contortus</i>. The experiment was conducted for 75 d (days), all animals were then slaughtered, and the abomasal tissues were examined for antioxidant parameters and histopathology. The concentration of malondialdehyde in the abomasal mucosa was lower in ARTMAL (<i>p</i> < 0.05), and the total antioxidant capacity was higher in MAL (<i>p</i> < 0.05), than in UNS. Increased mucus production was observed in the ARTMAL. The number of mast cells in UNS and ART was significantly higher than the number in MAL (<i>p</i> < 0.01 and <i>p</i> < 0.05). Plasma cell numbers were higher in ARTMAL than the number in MAL (<i>p</i> < 0.05). Abomasal tissue regenerated more frequently in ARTMAL. These results represent the first report of the impact of <i>A. absinthium</i> and <i>M. sylvestris</i> on antioxidant parameters and local immune responses of abomasal mucosa of lambs infected with a GIN parasite.