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Objective To evaluate the anti-infective effect of polysaccharide isolated from fungus PH1008 in vaginal Candida albicans infection model of mouse,and to provide a new and potential pathway to the development of anti-candida drugs. Methods Determination of gene expression level of transcriptome in mice vagina after yeast infection mouse model was treated by exopolysaccharide of fungus PH1008. Results The expression of hepatocyte growth factor and complement 1 receptor was increased, and the up-regulation was related to varied signal transduction pathways. Conclusions The anti-infection effect of Candida albicans can be induced by vaginal mucosal immunization with exopolysaccharide of fungus PH1008, and the relevant mechanism needs further research.