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Infection-related glomerulonephritis (IRGN) results from an immune-mediated process in the occurrence of non-renal infection. Despite increased incidence of infections post-transplant, which is attributed to the immunosuppression, IRGN serves to be a rare cause of de novo GN. Here, we present a 43-year old male, a deceased donor renal transplant recipient, who presented with acute decline in allograft function that developed in association with IRGN five years after transplant. He continued to have renal allograft dysfunction despite treatment with antibiotics. We infer that IRGN must be thought of as a possible entity, although rare, in the diagnosis of de novo GN post-transplant. Furthermore, the absence of definitive treatment protocol makes this emerging cause of renal allograft dysfunction be associated with the poor prognosis.