Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila
oleh: Maria Clara Guida, Ryan Tyge Birse, Alessandra Dall’Agnese, Paula Coutinho Toto, Soda Balla Diop, Antonello Mai, Peter D. Adams, Pier Lorenzo Puri, Rolf Bodmer
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-01-01 |
Deskripsi
Animal studies have shown that the nutritional status of parents can predispose the offspring to obesity and obesity-related diseases. Here the authors show that cardiac dysfunction induced by a high-fat diet persists for two generations in Drosophila, and that targeted expression of ATGL/bmm in the offspring, as well as inhibition of H3K27 trimethylation, is cardioprotective.