Similarity in viral and host promoters couples viral reactivation with host cell migration
oleh: Kathrin Bohn-Wippert, Erin N. Tevonian, Melina R. Megaridis, Roy D. Dar
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-05-01 |
Deskripsi
The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.