Similarity in viral and host promoters couples viral reactivation with host cell migration

oleh: Kathrin Bohn-Wippert, Erin N. Tevonian, Melina R. Megaridis, Roy D. Dar

Format: Article
Diterbitkan: Nature Portfolio 2017-05-01

Deskripsi

The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.