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COVID-19 Pandemic post threats to the life of millions of people across the globe as no specific therapeutics or vaccines have been scientifically proven. In this paper, we discussed the applications of nanoparticles in combating the COVID-19 Pandemic. Nanoparticles have indeed revolutionized medicine often employed for a variety of purposes including therapeutics, nano-devices, biosensors, vaccines, nano drugs, drug carriers, and set to combating the current menace of COVID-19 by providing immense solutions. Nanoparticles play role in tackling infectious diseases via the development of virus-like nanoparticles for the overall improving immune response, point-of-care diagnostic devices for rapid diagnoses, and nano-therapeutics for better treatment.