Mutual reinforcement between telomere capping and canonical Wnt signalling in the intestinal stem cell niche
oleh: Ting-Lin B. Yang, Qijun Chen, Jennifer T. Deng, Geetha Jagannathan, John W. Tobias, David C. Schultz, Shan Wang, Christopher J. Lengner, Anil K. Rustgi, John P. Lynch, F. Brad Johnson
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-03-01 |
Deskripsi
Mice lacking telomerase provide a model to study pathogenesis caused by critical telomere shortening. Here, the authors provide evidence that telomere shortening causes downregulation of Wnt signalling in intestinal crypts and that defects can be partially rescued by treatment with Wnt agonists.