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Background: A giant Cell tumour is a benign primary bone neoplasm that most often occurs in a periarticular location and typically involves the epiphyseal region of long bones. Foot involvement is rare, and isolated involvement of talus is even rarer. Case presentation: Here we report a case of a Campanacci grade 3 giant cell tumour of talus in an 18-year-old female, treated with en-bloc excision by a single incision and reconstruction by ankle and subtalar arthrodesis by allogenic talus. Discussion and conclusion: En bloc excision by a single incision and reconstruction by ankle and subtalar arthrodesis is a feasible option in the management of GCT of the talus. Anatomical reconstruction of the talus to fill the defect created and pan talar arthrodesis can be considered as a biological reconstruction method after excising the tumour. Level of evidence: V.