Epidermal Notch1 recruits RORγ+ group 3 innate lymphoid cells to orchestrate normal skin repair
oleh: Zhi Li, Tom Hodgkinson, Elizabeth J. Gothard, Soulmaz Boroumand, Rebecca Lamb, Ian Cummins, Priyanka Narang, Amy Sawtell, Jenny Coles, German Leonov, Andrea Reboldi, Christopher D. Buckley, Tom Cupedo, Christian Siebel, Ardeshir Bayat, Mark C. Coles, Carrie A. Ambler
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-04-01 |
Deskripsi
In normal skin, Notch directs keratinocytes to terminally differentiate. Here the authors show that Notch1 has a wider role in skin repair; Notch1 is activated in keratinocytes after damage and drives transcription of TNFα and inflammatory chemokines, which in turn recruit ILC3s and macrophages that promote repair.