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In this paper, a class of fractional integrodifferential equations of mixed type with time-varying generating operators and nonlocal conditions is considered. Using a contraction mapping principle and Krasnoselskii's fixed point theorem via Gronwall's inequality, the existence and uniqueness of mild solution are given. The existence of optimal pairs of systems governed by fractional integrodifferential equations of mixed type with time-varying generating operators and nonlocal conditions is also presented.