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We review our strategy to study hadron interactions from lattice QCD using newly proposed potential method. We first explain our strategy in the case of nuclear potentials and its application to nuclear physics. We then discuss the origin of the repulsive core, by adding strange quarks to the system. We also explore a possibility for H-dibaryon to exist in flavor SU(3) limit of lattice QCD. We conclude the paper with an application of our strategy to investigate the maximum mass of neutron stars.