Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences
oleh: Michael A. Skinnider, Chad W. Johnston, Mathusan Gunabalasingam, Nishanth J. Merwin, Agata M. Kieliszek, Robyn J. MacLellan, Haoxin Li, Michael R. M. Ranieri, Andrew L. H. Webster, My P. T. Cao, Annabelle Pfeifle, Norman Spencer, Q. Huy To, Dan Peter Wallace, Chris A. Dejong, Nathan A. Magarvey
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-11-01 |
Deskripsi
Large-scale sequencing efforts have uncovered a large number of secondary metabolic pathways, but the chemicals they synthesise remain unknown. Here the authors present PRISM 4, which predicts the chemical structures encoded by microbial genome sequences, including all classes of bacterial antibiotics in clinical use.