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This is a paper in the field of mineral processing engineering. According to the characteristics of a certain barite ore in Northwest China, such as uneven distribution of barite ore, uneven dissemination particle size of barite, and extremely close dissemination relationship between barite and quartz, a detailed beneficiation process test was carried out. The research results show that: Sodium silicate as depressant, oxygen fossil sodium soap as a collector, which can effectively realize the barium sulfate and gangue separation, using fast segmentation strengthened flotation technology, reduce the selected operation load and strengthening the comprehensive recovery of barium sulfate, small closed-circuit flotation tests with the grade of barium sulfate in the barite ore concentrate 89.16%, the SiO2 grade is 0.85%, recovery rate of barium sulfate 92.01% better technical index, barite ore concentrate products meet brick wells with barite powder quality standards.