Mechanism of regulation of the Helicobacter pylori Cagβ ATPase by CagZ
oleh: Xiuling Wu, Yanhe Zhao, Hong Zhang, Wendi Yang, Jinbo Yang, Lifang Sun, Meiqin Jiang, Qin Wang, Qianchao Wang, Xianren Ye, Xuewu Zhang, Yunkun Wu
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2023-01-01 |
Deskripsi
Cagβ is an ATPase in the H. pylori CagType4 secretion system essential for delivering the CagA effector to host cells. Here, authors present crystal structures of hexameric apo-Cagβ and Cagβ trapped in the monomeric state by its regulator CagZ, uncovering the regulatory mechanisms of Cagβ.