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Primary liposarcoma originating from the diaphragm is an extremely rare case. Seventy-four-year-old male presented to emergency department with worsening right upper quadrant abdominal pain with dyspnea. Contrast-enhanced computed tomography of the abdomen demonstrated lobulated mass in right hemidiaphragm exhibiting mass effects to adjacent structures compressing gall bladder. Magnetic resonance imaging of the abdomen showed diaphragmatic mass with heterogeneous signal intensities with partial diffusion restriction. Surgical removal was performed and histology confirmed dedifferentiated liposarcoma arising from the diaphragm with gall bladder invasion. Keywords: Liposarcoma, Dedifferentiated, Sarcoma, Diaphragm