Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells
oleh: Michael C. Nicastri, Vito W. Rebecca, Ravi K. Amaravadi, Jeffrey D. Winkler
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2018-01-01 |
Deskripsi
DQ661 is a novel dimeric quinacrine that affects multiple lysosomal functions (autophagy and macropinocytosis) and mTORC1 (mechanistic target of rapamycin) activity by specifically targeting protein-palmitoyl thioesterase 1 (PPT1). DQ661 has in vivo activity in immunocompetent mouse models of cancer, and constitutes a new tool compound for the study of lysosomal function in cancer and therapeutic resistance.