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Abstract Ultrasonic techniques are frequently used in organic molecule conformation analysis. Mixtures of ternary liquid complexes are extensively used for comprehending the strength as well as the characteristics of the interactions between molecules. Experimentally, the thermo physical properties of ternary liquid mixtures such as viscosity (η), density (ρ) and velocity (u) of K-contin, (2-Aminoacetamido)acetic acid and non-aqueous medium were determined over temperature ranges of 298.15, 308.15 and 318.15 K. The experimental data were used to ascertain the thermoacoustic parameters such as free volume, internal pressure, adiabatic compressibility, solvation number, specific acoustic impedance and intermolecular free length. These parameters are more useful for predicting and validating molecular interactions.