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Low dose isoflurane exerts opposing effects on neuronal network excitability in neocortex and hippocampus.
oleh: Klaus Becker, Matthias Eder, Andreas Ranft, Ludwig von Meyer, Walter Zieglgänsberger, Eberhard Kochs, Hans-Ulrich Dodt
Format: | Article |
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Diterbitkan: | Public Library of Science (PLoS) 2012-01-01 |
Deskripsi
The anesthetic excitement phase occurring during induction of anesthesia with volatile anesthetics is a well-known phenomenon in clinical practice. However, the physiological mechanisms underlying anesthetic-induced excitation are still unclear. Here we provide evidence from in vitro experiments performed on rat brain slices that the general anesthetic isoflurane at a concentration of about 0.1 mM can enhance neuronal network excitability in the hippocampus, while simultaneously reducing it in the neocortex. In contrast, isoflurane tissue concentrations above 0.3 mM expectedly caused a pronounced reduction in both brain regions. Neuronal network excitability was assessed by combining simultaneous multisite stimulation via a multielectrode array with recording intrinsic optical signals as a measure of neuronal population activity.