HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity
oleh: Jie Zheng, Chen Wang, Mi Ra Chang, Swapnil C. Devarkar, Brandon Schweibenz, Gogce C. Crynen, Ruben D. Garcia-Ordonez, Bruce D. Pascal, Scott J. Novick, Smita S. Patel, Joseph Marcotrigiano, Patrick R. Griffin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-12-01 |
Deskripsi
RIG-I is a critical receptor in the induction of innate immune responses, but mutations in RIG-I can be associated with hyperactive signalling and autoimmune disease. Here Zheng et al. apply HDX-MS approaches to reveal dysregulated checkpoints that result in recognition of self-derived RNA during RIG-I mediated autoimmunity.