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As an aromatic plant of the Labiatae family, Salvia officinalis L. (sage), is cultured worldwide, especially in Mediterranean region. The leaves of sage are used as a popular herbal tea, drug and seasoning. In the present study, eight novel C20-norabietane diterpenoids (salofficinoids A-H, 1–8), along with four known analogues (9–12) which were responsible for the anti-inflammatory activity, were purified from the sage leaves via bioassay-guided fractionation. Their structures were investigated using extensive spectroscopic analyses. The anti-inflammatory effects of all isolates on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophage cells were assessed. Among them, salofficinoids G (7), which exhibited the most potent NO inhibitory effect, was further evaluated, and its mechanism of action was explored.