Durable complete response for oligometastatic renal cell carcinoma with immune checkpoint inhibition and cytoreductive nephrectomy in a Jehovah’s witness: A case report
oleh: Tony Zibo Zhuang, Lara Harik, Lara Harik, Seth Force, Seth Force, Agreen Hadadi, Mehmet Asim Bilen, Mehmet Asim Bilen, Jacqueline T. Brown, Jacqueline T. Brown, Bradley C. Carthon, Bradley C. Carthon, Jamie Goldman, Jamie Goldman, Omer Kucuk, Omer Kucuk, Viraj A. Master, Viraj A. Master, Bassel Nazha, Bassel Nazha
| Format: | Article |
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| Diterbitkan: | Frontiers Media S.A. 2022-12-01 |
Deskripsi
The role of cytoreductive nephrectomy in patients with metastatic renal cell carcinoma is a subject of debate. We report a durable complete response in a 62-year-old man Jehovah’s Witness with metastatic clear cell renal cell carcinoma who received two cycles of nivolumab/ipilimumab followed by radical nephrectomy and metastasectomy of known pulmonary disease site, both without a clinical need for perioperative blood transfusions. The patient continues to be without evidence of disease and without additional need for systemic therapy over a year after his radical nephrectomy. The case highlights that cytoreductive nephrectomy continues to play a role in the era of immune checkpoint inhibitors.