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Calcium carbonate (CaCO₃) particles have attracted increasing attention as a promising material for drug delivery systems. In this study, coral remains were utilized as a raw material for a novel drug carrier. A series of pre-treatment and parameter experiments were conducted to synthesize sub-micron spherical CaCO₃ particles. The CaCO₃ particles exhibited uniform size distribution, with the minimum mean size being only 344 nm. The effects on the CaCO₃ crystal phases and particle sizes were also discussed in this study. Drug loading experiments were also conducted to assess the feasibility of the CaCO₃ drug carrier. We loaded TRITC-Dextran into CaCO₃ particles for the simulation experiments. The loading capacity reached up to 9.6 wt.%, which was as high as common drug carriers such as liposomes. In this study, we aimed not only to tackle the local environmental issues caused by coral remains, but also to synthesize a suitable drug carrier for cancer therapy using the outstanding properties and low cost of CaCO₃.