Aged garlic extract as a potential prophylactic to reduce the progression of endometriosis and associated pain burden
oleh: Emily Redwood, Emily Redwood, Virginie Lam, Virginie Lam, Ryusuke Takechi, Ryusuke Takechi, Deborah Anne Kerr, Deborah Anne Kerr, Connie Jackaman, Connie Jackaman, Arazu Sharif, Arazu Sharif, John Charles Louis Mamo, John Charles Louis Mamo
| Format: | Article |
|---|---|
| Diterbitkan: | Frontiers Media S.A. 2022-11-01 |
Deskripsi
Endometriosis is a complex and potentially debilitating condition that has major impact on quality of life. There is emerging evidence that biological compounds found in garlic (Allium sativum) may be effective for attenuating endometrial pain. Suggested mechanisms for efficacy include modulation of inflammation and potent antioxidant effects. Aged-garlic-extract (AGE) is a centuries old process describing ethanolic extracts of garlic bulbs for 12–20 months. The AGE formulation realised contains a complex array of stabilised biologics with significant immunomodulatory effects relevant to inflammatory conditions. This perspective article puts forward a hypothesis that AGE should be considered as a prophylactic to manage endometrial pain.