Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression
oleh: Jaskaren Kohli, Chen Ge, Eleni Fitsiou, Miriam Doepner, Simone M. Brandenburg, William J. Faller, Todd W. Ridky, Marco Demaria
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-12-01 |
Deskripsi
Cutaneous hyperpigmented lesions, including nevi, are populated by senescent melanocytes. Here the authors provide evidence for a novel strategy based on combining inhibition of the BCL-2 and MCL1 anti-apoptotic pathways that selectively eliminates senescent melanocytes in culture and in vivo.