Targeting anti-apoptotic pathways eliminates senescent melanocytes and leads to nevi regression

oleh: Jaskaren Kohli, Chen Ge, Eleni Fitsiou, Miriam Doepner, Simone M. Brandenburg, William J. Faller, Todd W. Ridky, Marco Demaria

Format: Article
Diterbitkan: Nature Portfolio 2022-12-01

Deskripsi

Cutaneous hyperpigmented lesions, including nevi, are populated by senescent melanocytes. Here the authors provide evidence for a novel strategy based on combining inhibition of the BCL-2 and MCL1 anti-apoptotic pathways that selectively eliminates senescent melanocytes in culture and in vivo.