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This report aims to present the experience of a nurse in a Transfusion Committee at public schools. Whole blood transfusion carries risks to the receiver. The formation of a Transfusion Committee is fundamental and it is included in this process. The role of the nurse in planning, implementation and evaluation of actions regarding a safe transfusion therapy is highlighted.. The result of the nurse’s performance is the construction of a committee with a solid foundation, which is internally known and a model for other institutions and, especially, by the reduction of transfusion complications.