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Abstract An accurate prediction of prognosis is important for clinical treatments of glioma. In this study, a multiparameter radiomic model is proposed for accurate prognostic prediction of glioma. Three kinds of region of interest were extracted from preoperative postcontrast T1‐weighted images and T2 fluid‐attenuated inversion recovery images acquired from 140 glioma patients. Radiomics score (Radscore) was calculated and the conventional image features and clinical molecular characteristics that may be related to progression‐free survival (PFS) were evaluated. Five uniparameter and various combinations of biparameter and multiparameter models based on above characteristics were built. The performance of these models was evaluated by concordance index (C index), and the nomogram of the multiparameter radiomic model was constructed. The results show that the proposed multiparameter radiomic model has a better prediction performance than other models. In the training and validation sets, the calibration curves of the multiparameter radiomic model for the 1‐, 2‐, and 3‐year PFS probability demonstrate a high consistence between predictions and observations. In conclusion, this study demonstrates that the multiparameter radiomic model based on Radscore, conventional image features and clinical molecular characteristics can improve the prediction accuracy of glioma prognosis, which could be informative for individualized treatments.