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Abstract Clinical case We report a case of rheumatoid arthritis‐associated peripheral ulcerative keratitis (PUK) successfully treated with tocilizumab. Despite being treated with systemic corticosteroids and several disease‐modifying antirheumatic drugs, evern though received corneal transplantation, the patient was still going to lose her sight. Tocilizumab resulted in a good response with control of her systemic illness and preventing the progress of corneal lesions. Discussion Tocilizumab may be an additional tool for the patients with rheumatoid arthritis associated PUK that is refractory to other drugs.