High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection
oleh: Eva-Maria Jacobsen, Dorit Fabricius, Magdalena Class, Fernando Topfstedt, Raquel Lorenzetti, Iga Janowska, Franziska Schmidt, Julian Staniek, Maria Zernickel, Thomas Stamminger, Andrea N. Dietz, Angela Zellmer, Manuel Hecht, Peter Rauch, Carmen Blum, Carolin Ludwig, Bernd Jahrsdörfer, Hubert Schrezenmeier, Maximilian Heeg, Benjamin Mayer, Alina Seidel, Rüdiger Groß, Jan Münch, Frank Kirchhoff, Sebastian F. N. Bode, Gudrun Strauss, Hanna Renk, Roland Elling, Maximillian Stich, Reinhard E. Voll, Burkhard Tönshof, Axel R. Franz, Philipp Henneke, Klaus-Michael Debatin, Marta Rizzi, Ales Janda
| Format: | Article |
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| Diterbitkan: | Nature Portfolio 2022-11-01 |
Deskripsi
Severity of SARS-CoV-2 infection is different in adults and children which involves the immune response. Here using a parent and children cohort with 4 month and 12 month sampling times, the authors show enhanced levels and increased breadth of anti-spike antibody level over time but reduced specific T cell and B cell numbers in children.