Total synthesis of (−)-epimyrtine by a gold-catalyzed hydroamination approach
oleh: Thi Thanh Huyen Trinh, Khanh Hung Nguyen, Patricia de Aguiar Amaral, Nicolas Gouault
| Format: | Article |
|---|---|
| Diterbitkan: | Beilstein-Institut 2013-10-01 |
Deskripsi
A new approach to the total synthesis of (−)-epimyrtine has been developed from D-alanine. The key step to access the enantiopure pyridone intermediate was achieved by a gold-mediated cyclization. Finally, various transformations afforded the natural product in a few steps and good overall yield.