Prognostic impact of genetic characterization in the GIMEMA LAM99P multicenter study for newly diagnosed acute myeloid leukemia
oleh: Francesco Lo-Coco, Antonio Cuneo, Fabrizio Pane, Daniela Cilloni, Daniela Diverio, Marco Mancini, Nicoletta Testoni, Antonella Bardi, Barbara Izzo, Niccolò Bolli, Roberta La Starza, Paola Fazi, Simona Iacobelli, Alfonso Piciocchi, Marco Vignetti, Sergio Amadori, Franco Mandelli, Pier Giuseppe Pelicci, Cristina Mecucci, Brunangelo Falini, Giuseppe Sagliofor the Acute Leukemia Working Party of the GIMEMA group, Giuseppe Sagliofor the Acute Leukemia Working Party of the GIMEMA group
| Format: | Article |
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| Diterbitkan: | Ferrata Storti Foundation 2008-07-01 |
Deskripsi
Background Recent advances in genetic characterization of acute myeloid leukemia indicate that combined cytogenetic and molecular analyses provide better definition of prognostic groups. The aim of this study was to verify this prospectively in a large group of patients.Design and Methods Genetic characterization was prospectively carried out in 397 patients with acute myeloid leukemia (median age, 46 years) receiving uniform treatment according to the LAM99P protocol of the Italian GIMEMA group. The impact of genetic markers on response to therapy and outcome was assessed by univariate and multivariate analyses.Results For induction response, conventional karyotyping identified three groups with complete remission rates of 92%, 67% and 39% (p