Recovering genotypes and phenotypes using allele-specific genes

oleh: Gamze Gürsoy, Nancy Lu, Sarah Wagner, Mark Gerstein

Format: Article
Diterbitkan: BMC 2021-09-01

Deskripsi

Abstract With the recent increase in RNA sequencing efforts using large cohorts of individuals, surveying allele-specific gene expression is becoming increasingly frequent. Here, we report that, despite not containing explicit variant information, a list of genes known to be allele-specific in an individual is enough to recover key variants and link the individuals back to their genotypes and phenotypes. This creates a privacy conundrum.