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Main point of prevention of tuberculosis is the existence of basic knowledge about risk factors (smoking habit, alchohol abuse) which contribute to appearance of tuberculosis and influence to therapy. In order to assess the influence of potential risk factors a cross-analysis was made for the years 2002-2004, 2007-2009 and 2012-2014 . During the period of 12 years, 230 cases of TB were included in the study. The mean age of all subjects was 45.81±16.98. There were (61.7-73.2%) males and this observation is supported by reports that males had significantly higher risk for more severe lung destruction (69.2-84.6%), as evidenced by bilateral lung cavitation (86.1-100%) than females. In total 45.6-76.7% were smear-positive. Alcohol use disorders increased (11.8-29.4%; p=0.02) as a smoking habit (44.1-47.1%). In cases with severe lung destruction as a lung cavitation increased cigarette smoking (46.6-60.0%) and alcoholism (19.4-50.0%; p=0.007). Linear regression analysis confirmed a statistically significant correlation between severe form of TB and smoking habit (>20 cigarettes per day, p=0.04) and alcohol use disorders (p=0.004). Successful control in reducing smoking, alcohol use disorders and, could favorably impact the TB morbidity rate.