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Abstract Probiotics are widely used for various fields, such as agriculture, food, and treatment and so on. Akkermansia muciniphila, the candidate for next‐generation probiotics, is an intestinal bacterium that was isolated from a human fecal sample. It has been proved that A. muciniphila is closely related to multiple disease and metabolic disorders. What's more, its functions are not limited to intestinal diseases only, and even affect aging and cognition. Therefore, we would like to summarize the related research progress on A. muciniphila though this review, which help us to learn its role in the microbial networks, as well as to understand its positive impacts on the health of animals and human.