Reference-free cell type deconvolution of multi-cellular pixel-resolution spatially resolved transcriptomics data
oleh: Brendan F. Miller, Feiyang Huang, Lyla Atta, Arpan Sahoo, Jean Fan
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-04-01 |
Deskripsi
Identifying cell-type-specific spatial patterns in ST data is critical for understanding tissue organization but current methods rely on external references. Here the authors develop a reference-free method to effectively recover cell-type transcriptional profiles and proportions.