New Derivatives of Lupeol and Their Biological Activity
oleh: Hoang-Thuy-Tien Le, Quoc-Cuong Chau, Thuc-Huy Duong, Quyen-Thien-Phuc Tran, Nguyen-Kim-Tuyen Pham, Thi-Hoai-Thu Nguyen, Ngoc-Hong Nguyen, Jirapast Sichaem
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2021-12-01 |
Deskripsi
The natural product lupeol (<b>1</b>) was isolated from <i>Bombax ceiba</i> leaves, which were used as starting material in the semisynthetic approach. Three new derivatives (<b>2a</b>, <b>2b</b>, and <b>3</b>) were synthesized using oxidation and aldolization. Their chemical structures were elucidated by spectroscopic analyses (HRESIMS and NMR). Compounds <b>3</b> showed significant <i>α</i>-glucosidase inhibition with an IC<sub>50</sub> value of 202 µM, whereas <b>2a</b> and <b>2b</b> were inactive.