Probing the Immune System Dynamics of the COVID-19 Disease for Vaccine Designing and Drug Repurposing Using Bioinformatics Tools
oleh: Deepshikha Yadav, Shriya Agarwal, Pranav Pancham, Divya Jindal, Vinayak Agarwal, Premshankar Kumar Dubey, Saurabh K. Jha, Shalini Mani, Rachana, Abhijit Dey, Niraj Kumar Jha, Kavindra Kumar Kesari, Manisha Singh
| Format: | Article |
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| Diterbitkan: | MDPI AG 2022-04-01 |
Deskripsi
The pathogenesis of COVID-19 is complicated by immune dysfunction. The impact of immune-based therapy in COVID-19 patients has been well documented, with some notable studies on the use of anti-cytokine medicines. However, the complexity of disease phenotypes, patient heterogeneity and the varying quality of evidence from immunotherapy studies provide problems in clinical decision-making. This review seeks to aid therapeutic decision-making by giving an overview of the immunological responses against COVID-19 disease that may contribute to the severity of the disease. We have extensively discussed theranostic methods for COVID-19 detection. With advancements in technology, bioinformatics has taken studies to a higher level. The paper also discusses the application of bioinformatics and machine learning tools for the diagnosis, vaccine design and drug repurposing against SARS-CoV-2.