mTORC1 coordinates an immediate unfolded protein response-related transcriptome in activated B cells preceding antibody secretion
oleh: Brian T. Gaudette, Derek D. Jones, Alexandra Bortnick, Yair Argon, David Allman
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-02-01 |
Deskripsi
Antibody production in plasma cells involves the unfold protein response (UPR), but how this is regulated is not clear. Here the authors show that mTORC1 signalling but not Xbp1-mediated transcription regulation in activated B cells is important for the induction of a UPR-related transcriptome that precedes full plasma cell functions.