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Transurethral Resection of Prostate (TURP) syndrome is a rare but serious complication characterized by fluid absorption, leading to life-threatening complications. Although renal insufficiency is frequently associated with the patients posted for TURP, there are no studies on the choice of irrigation fluid in patients with severe renal insufficiency. The safety of glycine has been demonstrated in mild to moderate renal insufficiency patients, but not in severe renal insufficiency patients requiring hemodialysis. We report a case of 68 year old male with severe renal insufficiency, who developed TURP syndrome with 1.5% glycine as irrigation fluid and discuss the role of various irrigation fluids in patients with severe renal insufficiency.