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The loss-of-function conditions for an <i>l(3)malignant brain tumour</i> (<i>l(3)mbt</i>) in larvae reared at 29 °C results in malignant brain tumours and hyperplastic imaginal discs. Unlike the former that have been extensively characterised, little is known about the latter. Here we report the results of a study of the hyperplastic <i>l(3)mbt</i> mutant wing imaginal discs. We identify the <i>l(3)mbt</i> wing disc tumour transcriptome and find it to include genes involved in reactive oxygen species (ROS) metabolism. Furthermore, we show the presence of oxidative stress in <i>l(3)mbt</i> hyperplastic discs, even in apoptosis-blocked conditions, but not in <i>l(3)mbt</i> brain tumours. We also find that chemically blocking oxidative stress in <i>l(3)mbt</i> wing discs reduces the incidence of wing disc overgrowths. Our results reveal the involvement of oxidative stress in <i>l(3)mbt</i> wing discs hyperplastic growth.