KEAP1 has a sweet spot: A new connection between intracellular glycosylation and redox stress signaling in cancer cells
oleh: Po-Han Chen, Jen-Tsan Chi, Michael Boyce
| Format: | Article |
|---|---|
| Diterbitkan: | Taylor & Francis Group 2017-11-01 |
Deskripsi
The KEAP1/NRF2 pathway is a master regulator of the redox stress response and is dysregulated in numerous human tumors. We discovered that NRF2 signaling is controlled by the site-specific glycosylation of KEAP1, revealing a potentially broad link among nutrient sensing, proteostasis and stress resistance in both normal and cancer cells.