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<p><em>OTX</em><strong> </strong>Homeobox genes are involved in embryonic morphogenesis and in the development of olfactory epithelium in adult. Mutations occurring in the <em>OTX </em>genes are reported to be associated to tumorigenisis in human. No reports correlate the expression of <em>OTX</em> genes and neoplasms of the nasal cavity. Thus, through immunohistochemical and Real-time PCR analysis we investigated <em>OTX1</em> and <em>OTX2</em> expression in the more frequent types of nasal and sinonasal tumours. Variable expression of both genes were found in normal sinonasal mucosa and in tumours. Interestingly, no expression of both <em>OTX </em>genes were detected in sinonasal intestinal-type adenocarcinomas; only <em>OTX1</em> was found in non-intestinal-type adenocarcinomas and <em>OTX2 </em>was selectively expressed in olfactory neuroblastomas. In conclusion, <em>OTX1</em> and <em>OTX2</em> genes might have a role in the pathogenesis of different types of sinonasal neoplasms.</p>