Intrinsically disordered intracellular domains control key features of the mechanically-gated ion channel PIEZO2
oleh: Clement Verkest, Irina Schaefer, Timo A. Nees, Na Wang, Juri M. Jegelka, Francisco J. Taberner, Stefan G. Lechner
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-03-01 |
Deskripsi
A key question in mechanobiology is how mechanical forces are transmitted to PIEZO ion channels. Here, Verkest et al. identify an intracellular channel domain that is required for the activation of PIEZO2 by cytoskeleton-transmitted forces.