Exocyst dynamics during vesicle tethering and fusion
oleh: Syed Mukhtar Ahmed, Hisayo Nishida-Fukuda, Yuchong Li, W. Hayes McDonald, Claudiu C. Gradinaru, Ian G. Macara
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-12-01 |
Deskripsi
Exocyst complex tethers vesicles to plasma membranes, but assembly mechanisms remain unclear. Here, the authors use Cas9 gene editing to tag exocyst components in epithelial cells, and find that exocyst subcomplexes are recruited to membranes independently, but are both needed for vesicle fusion.