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Abstract Discoveries of tetraquarks not only enrich the hadronic spectrum but also provide more platforms to understand quantum chromodynamics. We study the production processes of hidden-charm and open-charm tetraquarks in B decays by analyzing their topological amplitudes. Relations between different channels are found, which confront tests by experiments to probe the nature of the tetraquarks. Furthermore, promising channels to find more tetraquarks are proposed.